The effect of ischemia on cerebellar purkinje cell GABAA receptors

...........................................................................................viii Abbreviations used in text....................................................................xi CHAPTER 1: General Introduction.........................................................1 I. Cardiac Arrest and Cerebral Ischemia............................................1 II. The Cerebellum and Purkinje Cell Vulnerability to Ischemic Damage..............................................................................................3 III. Functional Role of GABAA Receptors During Ischemia ....................4 IV. Purkinje Cell GABAA Receptors, Pharmacology, and Plasticity...........6 V. Progesterone, Allopregnanolone, and Neuroprotection....................8 VI. Summary..................................................................................11 VII. Goals.......................................................................................11 CHAPTER 2: Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and Allopregnanolone neuroprotection is associated with GABAA receptor stabilization.............................................................13